Drugs of natural origin are an important part of the active substance portfolio produced by TAPI. Extracted from plant material, the isolated products are either used directly as APIs or serve as precursors for further partial synthesis. Our portfolio of natural products is extensive, ranging from standardized herbal extracts (e.g. Silymarin) through alkaloids (e.g. ergot alkaloids, cabergoline, Bromocriptine and Galantamine) to the most advanced products (e.g. Paclitaxel, Docetaxel).
The availability and quality of the biomass, usually of herbal origin, are key factors for the isolation of natural products. We have our own growth technologies and our own cultivars or strains developed by long-term selection and breeding, such as the silybin cultivar of Silybum marianum, or the ergot strains that produce the required spectrum of alkaloids. In other cases, TAPI experts collaborate with horticultural companies worldwide.
The principal technology for isolating natural products involves extracting herbal material using batteries of percolators or continual carousel-type extractors, followed by further processing of the obtained primary extract. Process-scale chromatography is often used for the isolation of natural products.