Pregabalin

Pregabalin is a compound that is chemically and structurally similar to gabapentin, with antiepileptic, analgesic, and anxiolytic properties. Pregabalin has been studied for use in a variety of disorders, including as add-on and monotherapy in refractory partial seizures, diabetic neuropathy, surgical dental pain and other pain syndromes, postherpetic neuralgia, and social anxiety disorders.

Pregabalin’s innovator is Pfizer-Global and appears world-wide under the brand name Lyrica.

Pregabalin is a structural analogue of gamma-aminobutyric acid (GABA) and has anxiolytic, analgesic, and antiepileptic properties. Pregabalin is structurally related to gabapentin. The exact mechanism of action of pregabalin as an antiseizure agent has not been determined. Pregabalin does not show direct GABA-mimetic effects, but increases neuronal GABA levels as well as produces a dose-dependent increase in glutamic acid decarboxylase activity. Pregabalin reduces neuronal calcium currents by binding to the alpha-2-delta subunit of calcium channels, and this particular mechanism may be responsible for effects in neuropathic pain, anxiety, and other pain syndromes. Pregabalin does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.

Pregabalin appears in the following formulation and dosage:
Capsules: 25, 50, 75, 100, 150, 200, 225, 300 MG

General data on Pregabalin Active Pharmaceutical Ingredient

CAS Registry: 148553-50-8
ATC: N03AX16
Molecular Formula: C8H17NO2
Molecular Weight: 159.2

TAPI's Pregabalin Pharmaceutical Ingredient

TAPI's Pregabalin Active Pharmaceutical Ingredient is produced in Assia Chemical Industries Limited - Teva Tech site in Beer Sheva, Israel.

Pregabalin is produced by TAPI by Organic synthesis and considered to be medium-high volume Active Pharmaceutical Ingredient.
 
2008 Available DMF: U.S. DMF.

TAPI provide full service on Pregabalin and other APIs in our portfolio. Our local sales offices provide full information on our product, regulatory compliance and documentation on Pregabalin. Contact us today for further inquiries and samples and kilograms availability information for TAPI's Pregabalin.

Another product, in the group of ANTIEPILEPTIC - Gaba analouges available on TAPI's portfolio is Gabapentin. Contact us today for information on these products.

Legal Note

Product exploitation, including development, sales and offer for sale are performed where permissible by patent law. This presentation is not and should not constitute an offer for sale in territories where it is not permitted by law. In USA Products  that  Currently on Patent are available for R&D Use in Accordance with 35 USC §271 (e) (1).

*TAPI stands for Teva's Active Pharmaceutical Ingredients