Fluticasone Propionate

Fluticasone Propionate is a medium-potency synthetic corticosteroid. It is used topically to relieve the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and psoriasis, intranasally for symptoms of allergic and non-allergic rhinitis, and by oral inhalation for asthma. Fluticasone Propionate inhalations are also used clinically in certain patients with chronic obstructive pulmonary disease (COPD).
Fluticasone Propionate‘s innovator is GSK-Global and is known world-wide by the brand names: Cutivate, Flonase, Flovent, Flovent Rotadisk and Flovent Hfa.

Topical corticosteroids, such as Fluticasone Propionate, exhibit anti-inflammatory, antipruritic, and vasoconstrictive properties. At the cellular level, corticosteroids induce peptides called lipocortins. Lipocortins antagonize phospholipase A2, an enzyme which causes the breakdown of leukocyte lysosomal membranes to release arachidonic acid. This action decreases the subsequent formation and release of endogenous inflammatory mediators including prostaglandins, kinins, histamine, liposomal enzymes and the complement system. Clinically, these actions correspond to decreased edema, erythema, pruritus, plaque formation and scaling of the affected skin.

In the treatment of asthma, orally inhaled corticosteroids block the late phase allergic response to allergens. Different cell types are responsible for release of mediators involved in the pathogenesis of asthma, including airway epithelium, eosinophils, basophils, lung parenchyma and more. Corticosteroids, such as Fluticasone Propionate, inhibit the release of these mediators as well as inhibit IgE synthesis, attenuate mucous secretion and eicosanoid generation, up-regulate beta-receptors, promote vasoconstriction, and suppress inflammatory cell influx and inflammatory processes. Clinical effects in asthma include a reduction in bronchial hyperresponsiveness to allergens, a decreased number of asthma exacerbations, and an improvement in FEV1, peak-flow rate, and respiratory symptoms.

Fluticasone Propionate appears in the following formulation and dosage:
Inhalation powder: 0.044 mg/Actuation, 0.11 mg/Actuation and 0.22 mg/Actutation.
Nasal spray: 0.05 mg/Actuation
Topical Cream: 0.05%
Topical Lotion/Solution: 0.05%
Topical Ointment: 0.05%

General data on Fluticasone Propionate Active Pharmaceutical Ingredient

CAS Registry: 80474-14-2
ATC: D07AC17; R01AD08; R03BA05
Molecular Formula: C25H31F3O5S
Molecular Weight: 500.6
Pharmacopoeias: In Eur. and US.

Ph. Eur. 5.5: Fluticasone Propionate is a white or almost white powder. Fluticasone Propionate is practically insoluble in water; slightly soluble in alcohol; sparingly soluble in dichloromethane.
USP 30: Fluticasone Propionate is micronised. Fluticasone propionate is a fine white powder.

TAPI's Fluticasone Propionate Pharmaceutical Ingredient

TAPI's Fluticasone Propionate Active Pharmaceutical Ingredient is produced in Sicor de Mexico S.A. de C.V. in Lerma Estado de Mexico, Mexico.

Drospirenone is highly potent active pharmaceutical ingredients, belongs to the hormone contraceptive and replacement therapy group of drugs. These drugs are highly potent active pharmaceutical ingredients that need special handle in production or preparation. As highly potent drug, Drosperinone is considered to be small volume Active Pharmaceutical Ingredient.

TAPI provide full service on Fluticasone Propionate and other APIs in our portfolio. Our local sales offices provide full information on our product, regulatory compliance and documentation on Fluticasone Propionate. Contact us today for further inquiries and samples and kilograms availability information for TAPI's Fluticasone Propionate.

TAPI is a world leading developer and manufacturer of highly potent drugs used by innovative and generic companies to formulate their final dosage medications. TAPI highly potent manufacturing plants are located mainly in Italy (Sicor S.r.l. ) and Mexico ( Sicor de Mexico) . TAPI highly potent active pharmaceutical ingredients, such as Fluticasone Propionate, are used in oral, parenteral, topical and inhalation therapies; and most fall in four classes: Steroids, Oncolytics, Hormones, Non-depolarizing muscle relaxants, Immunosuppressants. Amongst those can be  found product such as as Alclometasone Dipropionate, Amcinonide,Betamethasone, Clobetasone Butyrate, Beclometasone, Budesonide, Clobetasone, Deflazacort , Desoximetasone, Fluocinolone acetonide, Fluocinonide, Clobetasole propionate, Methylprednisolone, Mometasone furoate, Drospirenone, Halcinonide, Prednicarbate and Prednisone

Contact us today for information on TAPI's Fluticasone Propionate, and other highly potent Active Pharmaceutical Ingredients.

Legal Note

Product exploitation, including development, sales and offer for sale are performed where permissible by patent law. This presentation is not and should not constitute an offer for sale in territories where it is not permitted by law. In USA Products  that  Currently on Patent are available for R&D Use in Accordance with 35 USC §271 (e) (1).

*TAPI stands for Teva's Active Pharmaceutical Ingredients