Diltiazem Hydrochloride belongs to the well known group of Calcium Channels Blockers for treatment of cardiovascular conditions.  Diltiazem Hydrochloride, a benzothiazepine derivative, is a calcium antagonist which interferes with the influx of extracellular calcium through "slow" channels located in the cell membrane of cardiac smooth muscle. Diltiazem Hydrochloride is indicated for the treatment of hypertension. Diltiazem Hydrochloride may be used alone or in combination with other antihypertensive medications. It is also indicated for the management of chronic stable angina. Diltiazem Hydrochloride is marketed worldwide by innovative and generic companies. Most known brand names of Diltiazem Hydrochloride are Cardizem CD, Cardizem LA, Cartia XT, Dilacor XR, Diltia XT and  Tiazac.
Diltiazem Hydrochloride is formulated as plain or extended release tablets containing either 120 mg, 180 mg, 240 mg, 300 mg, 360 mg or 420 mg of Diltiazem Hydrochloride.

Traditionally, calcium-channel blockers have been classified according to their chemical structure; other methods of classification relate to the subtypes of calcium channels which they block, and their effects on heart rate. There are three major groups that are highly specific blockers of calcium channels: Dihydropyridine calcium-channel blockers (such as Nifedipine) act on slow, L-type channels. Benzothiazepine calcium-channel blockers (such as Diltiazem hydrochloride)  and Phenylalkylamine calcium-channel blockers (such as Verapamil) also act on L-type channels but they have less selective vasodilator activity than dihydropyridine derivatives.

General data on Diltiazem Hydrochloride Active Pharmaceutical Ingredient:

CAS Registry: 42399-41-7 (diltiazem);33286-22-5 (diltiazem hydrochloride);
ATC:C08DB01
Molecular Formula of Diltiazem Hydrochloride: C22H26N2O4S,HCl
Molecular Weight of Diltiazem Hydrochloride: 451.0

TAPI's Diltiazem Hydrochloride

TAPI's* Diltiazem Hydrochloride active pharmaceutical ingredient is produced in Assia Industries Limited – ABIC  site in Netanya, Israel.

Diltiazem Hydrochloride produced by TAPI since 1988  by organic synthesis  in a dedicated  production plant. It is considered to be high volume Active Pharmaceutical Ingredient. Through the years, TAPI has acquired vast experience in the production of Diltiazem Hydrochlride and it is one of the principal producers of this API.  TAPI's Diltiazem Hydrochloride poses highest quality and sold by TAPI all over the world. It complies with all Pharmacopoeias (for Pharmacopoeias info see information under Pahrmacopoeias paragraph).

Available DMFs from TAPI : USDMF , EU CTD & COS, JP DMF

TAPI provides full service on  Diltiazem Hydrochloride product and other APIs in our portfolio. We provide information on TAPI's Diltiazem Hydrochloride, the regulatory compliance with various health regulations and documentation. Contact us today for further inquiries and samples and kilograms availability information for TAPI's Diltiazem Hydrochloride.

Other active pharmaceutical ingredients, in the group of Calcium Channel Blockers, available on TAPI's portfolio are: Verapamil, Nifedipine and Amlodipine. Contact us today for information on these products.

Pharmacopoeias Info for Diltiazem Hydrochloride

Pharmacopoeias:In Chin., Eur., Jpn, and US.
Ph. Eur. 5.5 (Diltiazem Hydrochloride). A white crystalline powder. Freely soluble in water, in dichloromethane, and in methyl alcohol; slightly soluble in dehydrated alcohol. The pH of a 1% solution in water is 4.3 to 5.3. Store in airtight containers. Protect from light.
USP 29 (Diltiazem Hydrochloride). A white, odourless, crystalline powder, or small crystals. Freely soluble in water, in chloroform, in formic acid, and in methyl alcohol; sparingly soluble in dehydrated alcohol; insoluble in ether. Store in airtight containers. Protect from light.

Legal Note

Product exploitation, including development, sales and offer for sale are performed where permissible by patent law. This presentation is not and should not constitute an offer for sale in territories where it is not permitted by law.